Lack of Vitamin D Worsening of Asthma
February 6th, 2010 | by rarzi |Lack of Vitamin D Worsening of Asthma
Saturday, January 30, 2010 | 13:10 pm
KOMPAS.com – Patients with asthma are deficient in vitamin D will experience a worsening of asthma. This vitamin deficiency is expected to block the response to steroid treatment is often used in drug and control asthma salve.
In his research, researchers at National Jewish Health (NJH) in Denver to measure vitamin D levels from 50 patients with asthma and assess lung function, hyper-responsiveness airways, which commonly occurs in the airways shrinkage, and reactions to steroid treatment.
Apparently, patients who have vitamin D deficiency showed poor results in the examination of lung function and hyper-responsiveness airways. Moreover, patients with vitamin D levels in the body below 30 nanograms / mL levels of hyper-responsiveness airways almost doubled, compared with those who had more vitamin D in their blood.
The level of low vitamin D is also associated with poorer response to steroid treatment and increased production of pro-inflammatory cytokine, TNF-alpha. It increases the possibility that vitamin D levels are associated with an increased lower airway inflammation, the researchers said.
In addition, vitamin D levels to predict how well someone will respond to steroid treatment for asthma. “That may be because vitamin D acts as a steroid response modifiers in a way that is consistent with people suffering from asthma,” said Dr E Rand Sutherland, from the division of pulmonary and critical medical care at NJH.
Participants have the worst levels of the lowest vitamin D, they said. Asthma associated with obesity, and lack of vitamin D may be a factor linking these two conditions, said Sutherland.
“Restoring normal levels of vitamin D in people with asthma may help improve their asthma,” Sutherland said. However, it is unknown whether vitamin D intake will help people with asthma, he said.
Vitamin D intake for adults is 300 IU recommended to 600 IU, depending on the age, said the U.S. National Institutes of Health.
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